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KMID : 0918520130130010020
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Journal of the Korean Society of Inherited Metabolic Disease
2013 Volume.13 No. 1 p.20 ~ p.29
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Overview on Inborn Error of Metabolism involving Hepatic System
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Yoo Han-Wook
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Abstract
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Inborn error of metabolism usually presents with a constellation of clinical pictures involving multiorgan systems. Because of its rarity and clinical diversity, it is difficult to make diagnosis accurately and efficiently. Many inborn error of metabolism shows predominantly hepatic symptoms and signs. The onset of symptoms is also varying depending the disease. The onset might be even prenatal, either neonatal or infantile, and late childhood. The major manifestation patterns are jaundice or cholestasis, hepatomegaly with or without splenomegaly, hypoglycemia and acute or chronic hepatocellular dysfunction. Based on pronounced hepatic symptoms and onset of symptoms, differential diagnosis can be more easily made with subsequent further laboratory investigation. In this review paper, major inborn error of metabolism with hepatic symptoms are described from the perspective of mode of clinical presentations.
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KEYWORD
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Inborn error of metabolism, Hepatic system, Jaundice, Hepatomegaly, Hepatocellular dysfunction, Onset of symptoms
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